Our programmes
Our approach
We provide access to centralised expertise and operational support to accelerate exceptional academic science into attractive biotech assets.
Our deep and broad expertise ensures that we can identify and develop promising therapeutic candidates efficiently, giving them the attention they deserve. For us, the right molecule, brought into Slingshot at the right time, means groundbreaking treatments, delivered earlier.
When looking for ideas; we seek:
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World-leading scientists
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Targeted disease understanding
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Clear development pathways
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Significant unmet medical need

Building a diverse pipeline of
high-potential programmes
Our assets
ALTx Therapeutics
SSTX—002 | SSTX—003
Multiple small molecule therapeutics for the treatment of cancers that make use of the Alternative Lengthening of Telomeres (ALT) pathway.

Executive summary
- Indication: Targeted oncology for cancers dependent on the Alternative Lengthening of Telomeres (ALT) pathway
- Target: Multiple novel targets
- Founding scientist: Dr. Simon J. Boulton, Francis Crick Institute
Programme overview
10-15% of all cancers rely on the ALT pathway to elongate their telomeres, as a mechanism to escape telomere crisis and promote tumour growth. Reliance on ALT introduces unique vulnerabilities in these cancers that can be exploited to specifically kill these tumour cells.
Dr. Simon J. Boulton’s work at the Francis Crick Institute has systematically explored, identified and characterized these vulnerabilities and ALTx stems from these insights. ALTx is developing first in class therapeutics against novel targets to exploit the most promising of these vulnerabilities. The company operates through a deep hands-on collaboration with the Francis Crick Institute.
Founding team
Apini
SSTX—001
Novel small molecule therapeutics for the treatment of inflammatory diseases without induction of immune suppression.

Executive summary
- Target: eNAMPT
- Indication: Inflammatory diseases
- Stage: Hit to lead
- Founding scientist: Professor Sam Butterworth, University of Manchester
Programme overview
There remains unmet need in chronic inflammatory diseases. Our mission is to maximise the potential of targeting extracellular nicotinamide phosphoribosyl transferase (eNAMPT) as a novel treatment for chronic inflammation. Apini stems from work of Professor Sam Butterworth, University of Manchester, in collaboration with Professor Paul Caton, King’s College London, and exploits proprietary small molecules that modulate eNAMPT.
Target potential
Inhibiting eNAMPT has potential to treat inflammatory diseases without induction of immune suppression. Preclinical studies have demonstrated the potential for selective eNAMPT inhibitors to be applied across multiple chronic inflammatory diseases.
Scientific founder

Professor Sam Butterworth
Founder
Sam has 20 years’ experience in drug discovery and medicinal chemistry projects, including leading compound design and IP strategy, predominantly focusing on oncology, inflammatory and metabolic diseases.
Prior to his current academic career, Sam spent eight years with AstraZeneca where he invented the targeted anti-cancer agent AZD9291, which is now AstraZeneca’s bestselling drug osimertinib/Tagrisso.
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